Methyl (R)-2-(2-chlorophenyl)-2-(3-nitrophenylsulfonyloxy)acetate
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چکیده
منابع مشابه
Methyl (R)-2-(2-chlorophenyl)-2-(3-nitrophenylsulfonyloxy)acetate
The reaction between methyl (R)-2-(2-chloro-phen-yl)-2-hy-droxy-acetate and 3-nitro-benzene-sulfonyl chloride gave the title compound, C(15)H(12)ClNO(7)S, which is a promising inter-mediate for the synthesis of Clopidrogel, an anti-platelet drug used in the prevention of strokes and heart attacks. In the crystal, mol-ecules are linked through C-H⋯O interactions, and there is also a short Cl⋯O c...
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In the title mol-ecule, C(21)H(19)ClO(3), the cyclo-hexene ring adopts an envelope conformation, with all substituents equatorial. The plane through its five coplanar atoms makes dihedral angles of 12.75 (14) and 74.16 (8)° with the phenyl and benzene rings, respectively. The dihedral angle between the latter two rings is 81.73 (12)°. Inter-molecular C-H⋯O hydrogen bonds and intra-molecular C-H...
متن کاملInhibition of hepatic lipid biosynthesis by 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine) ethanol, a hypocholesterolemic agent.
1. G. J. Dutton and B. Burchell, Prog. Drug. Metab. 2, 1 (1977). 2. C. H. Gunn, J, Hered. 29, 137 (1938). 3. G. A. Lathe and M. Walker, Biochem. J. 67, 9P (1957). 4. J. Carbone and G. M. Grodsky, Proc. Soc. exp. biol. Med. 94, 449 (1957). 5. R. Schmid, J. Axelrod, L. Hammaker and R. L. Swarm, J. clin. Invest. 37, 1123 (1958). 6. I. M. Arias, Biochem. biophys. Res. Commun. 6, 81 (1961). 7. I. H....
متن کاملMethyl 3-(2-chlorophenyl)-2-(1H-indol-3-ylmethyl)-5-[1-(4-methoxyphenyl)-4-oxo-3-phenylazetidin-2-yl]-4-nitropyrrolidine-2-carboxylate
In the mol-ecule of the title compound, C(37)H(33)ClN(4)O(6), the four-membered β-lactam ring is essentially planar and is oriented at dihedral angles of 30.0 (1), 76.3 (1) and 30.9 (1)° with respect to the methoxy-phenyl ring, the phenyl ring and the indole unit, respectively. The pyrrolidine ring adopts a twist conformation. Intra-molecular C-H⋯Cl and C-H⋯O hydrogen bonds result in the format...
متن کامل2-Methyl-2-(3-nitrophenyl)-1,3-dithiane
The title compound, C(11)H(13)NO(2)S(2), contains a 1,3-dithiane ring in an almost ideal chair conformation with the following puckering parameters: Q = 0.7252 (15) Å, θ = 6.71 (13) and ϕ = 50.4 (11)°. The benzene ring occupies an axial position at the dithiane ring. The nitro group is almost coplanar with the benzene ring [O-N-C-C = -3.2 (2)°]. The mol-ecule has an L-shape with a C-C-C-C torsi...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2012
ISSN: 1600-5368
DOI: 10.1107/s1600536812020016